MyBioSource.com's RABBIT ANTI CDKN2A is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Western Blot. The RABBIT ANTI CDKN2A Antibody was generated using ARF, CDKN2A, CMM2, P16, p16 INK4a, P16INK4, and p16INK4a as the antigen and it reacts with Human, Mouse, and Rat.
Description
MBS222939 recognises human cyclin-dependent kinase inhibitor 2A (CDKN2A), a 16kDa protein belonging to the CDKN2 cyclin dependent kinase inhibitor family. CDKN2A acts as a negative regulator of cell proliferation by interacting strongly with CDK4 and CDK6, thus inhibiting their ability to interact with cyclin D and to phosphorylate the retinoblastoma protein. CDKN2A is an important tumour suppressor and defects in its production results in tumour formation in a wide range of tissues, including cutaneous malignant melanoma and Li-Fraumeni syndrome